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Isosteresin Medicinal Chemistry Group Meeting Christos ...

www.scripps.edu

biological activity. Thornber(1979): Groups or molecules which have chemical and physical similarities producing broadly similar biological effects. Parameters affected with bioisostericreplacements Size, conformation, inductive and mesomericeffects, polarizability, H-bond formation capacity, pK a, solubility, hydrophobicity, reactivity, stability.

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