AlphaFold: Improved protein structure prediction using ...

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AlphaFold: Improved protein structure prediction using1potentials from deep learning2Andrew W. Senior1 , Richard Evans1 , John Jumper1 , James Kirkpatrick1 , Laurent Sifre1 , Tim Green1,3Chongli Qin1, Augustin Z dek1, Alexander W. R. Nelson1, Alex Bridgland1, Hugo Penedones1,4Stig Petersen1, Karen Simonyan1, Steve Crossan1, Pushmeet Kohli1, David T. Jones2,3, David Silver1,5Koray Kavukcuoglu1, Demis Hassabis161DeepMind, London, UK72The Francis Crick Institute, London, UK83University College London, London, UK9 These authors contributed equally to this structure prediction aims to determine the three-dimensional shape of a protein from11its amino acid sequence1.

30 function and malfunction of these proteins, especially in cases where no homologous proteins have been experimentally determined7. 31 32 Proteins are at the core of most biological processes. Since the function of a protein is 33 dependent on its structure, understanding protein structure has been a grand challenge in biology 34 for decades ...

  Structure, Functions, Prediction, Protein, Protein structure, Protein structure prediction