Application Note - Agilent
AuthorsMichael C. zumwalt , PhDAgilent Technologies, , COUSAChristine Moore, PhDImmunalysis, , CAUSAAbstract A fast, sensitive and reproducible technique for confirm-ing the presence of drugs of abuse (DOA) in oral fluids(OF) using the Agilent G6410AA Triple Quadrupole MassSpectrometer (QQQ) is presented. The sensitivity of theQQQ easily meets the cutoff levels required by the UnitedStates Substance Abuse and Mental Health ServicesAdministration (SAMHSA) for workplace testing. TheDOA analyzed in this work include THC, cocaine, amphet-amine, methamphetamine, and MDMA ("Ecstasy") in OFs,which have been prepared using solid phase extraction(SPE). The sample preparation is then followed byreverse-phase LC/MS/MS using a m, C18 columnfor high-chromatographic resolution with high-speedseparation. As a result, elution times for both analytes andinternal standards are less than minutes for THC, andless than minutes for the remaining drugs.
Authors Michael C. Zumwalt, PhD Agilent Technologies, Inc. Englewood, CO USA Christine Moore, PhD Immunalysis, Corp. Pomona, CA USA Abstract A fast, sensitive and reproducible technique for confirm-
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