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DOSE LIMITING TOXICITIES (DLT) Example : Escalation ...

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dose escalation is stopped, and this dose is declared the maximally administered dose. Three (3) additional subjects will be entered at the next lowest dose level if only 3 subjects were treated previously at that dose. <1 out of 6 at highest dose level below the maximally administered dose This is generally the maximum tolerated dose (MTD).

  Escalation

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