ENZYMES

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ENZYMESSECOND EDITIONEnzymes: A Practical Introduction to Structure, Mechanism, and Data A. CopelandCopyright 2000 by Wiley-VCH, : 0-471-35929-7 (Hardback); 0-471-22063-9 (Electronic)ENZYMESA Practical Introductionto Structure, Mechanism,and Data AnalysisSECOND EDITIONRobert A. CopelandA JOHN WILEY & SONS, INC., PUBLICATIONNew York / Chichester / Weinheim / Brisbane / Singapore / TorontoDesignations used by companies to distinguish their products are often claimed as trademarks. Inall instances where John Wiley & Sons, Inc., is aware of a claim, the product names appear ininitial capital or . Readers, however, should contact the appropriatecompanies for more complete information regarding trademarks and part of this publication may be reproduced, stored in a retrieval system or transmitted in anyform or by any means, electronic or mechanical, including uploading, downloading, printing,decompiling, recording or otherwise, except as permitted under Sections 1

CONTENTS Preface xi Acknowledgments xiii Preface to the First Edition xv 1 A Brief History of Enzymology 1 1.1 Enzymes in Antiquity / 2 1.2 Early Enzymology / 3

  Enzymes