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ENZYMES

ENZYMESSECOND EDITIONE nzymes: A Practical Introduction to Structure, Mechanism, and Data A. CopelandCopyright 2000 by Wiley-VCH, : 0-471-35929-7 (Hardback); 0-471-22063-9 (Electronic)ENZYMESA Practical Introductionto Structure, Mechanism,and Data AnalysisSECOND EDITIONR obert A. CopelandA JOHN WILEY & SONS, INC., PUBLICATIONNew York / Chichester / Weinheim / Brisbane / Singapore / TorontoDesignations used by companies to distinguish their products are often claimed as trademarks. Inall instances where John Wiley & Sons, Inc., is aware of a claim, the product names appear ininitial capital or . Readers, however, should contact the appropriatecompanies for more complete information regarding trademarks and part of this publication may be reproduced, stored in a retrieval system or transmitted in anyform or by any means, electronic or mechanical, including uploading, downloading, printing,decompiling, recording or otherwise, except as permitted under Sections

CONTENTS Preface xi Acknowledgments xiii Preface to the First Edition xv 1 A Brief History of Enzymology 1 1.1 Enzymes in Antiquity / 2 1.2 Early Enzymology / 3

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