limma Linear Models for Microarray and RNA-Seq Data …

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limma : Linear Models for Microarray and RNA-Seq DataUser s GuideGordon K. Smyth, Matthew Ritchie, Natalie Thorne,James Wettenhall, Wei Shi and Yifang HuBioinformatics Division, The Walter and Eliza Hall Instituteof Medical Research, Melbourne, AustraliaFirst edition 2 December 2002Last revised 14 November 2021This free open-source software implements academic researchby the authors and co-workers. If you use it, please supportthe project by citing the appropriate journal articles listed inSection Introduction52 Citinglimma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Installation.

Limma is a package for the analysis of gene expression data arising from microarray or RNA-seq technologies [32]. A core capability is the use of linear models to assess di erential expression in the context of multifactor designed experiments. Limma provides the ability to analyze comparisons between many RNA targets simultaneously.

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