Methodologic Issues in Epidemiologic Risk Assessment

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Methodologic Issues in Epidemiologic Risk AssessmentMarkku Nurminen,' Tuula Nurminen, ' and Carlos F. Corvalan2This paper reviews Methodologic Issues pertinent to theapplication of epidemiology in risk Assessment and discussesconcerns in the presentation of results from such an of the health risks associated with occupational andenvironmental exposures involves four phases: hazardidentification, ie, the detection of the potential for agents tocause adverse health effects in exposed populations; exposureassessment, ie, the quantification of exposures and theestimation of the characteristics and sizes of the exposedpopulations; dose-response Assessment , ie, the modeling for riskrealization; and risk characterization, ie, the evaluation of theimpact of a change in exposure levels on public health risk Assessment process involves limitations of exposuredata, many assumptions, and subjective choices that need to beconsidered when using this approach to provide guidance forhealth policy or action.

Methodologic Issues in Epidemiologic Risk Assessment Markku Nurminen,' Tuula Nurminen, ' and Carlos F. Corvalan 2 This paper reviews methodologic issues pertinent to the

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