MULTIPLE SCLEROSIS FUNCTIONAL COMPOSITE
ADMINISTRATIONANDSCORING MANUAL Manual Prepared ByJill S. Fischer, J. Jak, E. Kniker, A. Rudick, Center for MS Treatment and ResearchCleveland Clinic FoundationCleveland, OhioGary Cutter, Cancer Research CenterDenver, ColoradoADMINISTRATIONANDSCORING MANUAL Revised, October 2001MULTIPLE SCLEROSIS FUNCTIONAL COMPOSITE (MSFC)ACKNOWLEDGMENTSThe MS FUNCTIONAL COMPOSITE (MSFC) was developed by theNational MS Society s Clinical Outcomes Assessment TaskForce, chaired by Richard Rudick, MD. The work of the TaskForce was supported by an unrestricted grant to the NationalMS Society from Berlex Pharmaceuticals. Members of the TaskForce included: Jack Antel, MD; Christian Confavreux, MD;Gary Cutter, PhD; George Ellison, MD; Jill Fischer, PhD; FredLublin, MD; Aaron Miller, MD; John Petkau, PhD; Stephen Rao,PhD; Stephen Reingold, PhD; Karl Syndulko, PhD; AlanThompson, MD; Joy Wallenberg, MD; Brian Weinshenker, MD;and Ernest Willoughby, MD.
scales of physical disability, such as the Expanded Disability Status Scale (EDSS) (1), or clinical measures of disease activity, such as the number of relapses. In February 1994 a
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