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Renal Functions Lecture-4

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1The KidneysDr. Khalid Al-AniDepartment of Clinical PharmacyFaculty of PharmacyLecture-4Renal FunctionsExcretion of waste -Production of urine-elimination of metabolic end products (Urea, Creatinine, uric acid ...etc)-elimination of foreign materials (Drugs)Control of volume & composition of ECF-Water and electrolyte balance-Acid/Base statusDr. Khalid Al-AniRenal FunctionsEndocrine Functions -renin erythropoietin Calcitriol ( activation of vitamin D)Why Test Renal Function?uTo identify Renal diagnose Renal monitor disease monitor response to assess changes in function that may impact on therapy ( , chemotherapy).Dr. Khalid Al-Ani2Renal Anatomy and Physiologyupair of fist-sized organs located on either side of the spinal column just behind the lower abdomen (L 1-3) Renal Anatomy and PhysiologyuConsists of Renal cortex and Renal functional unit of the kidney is the nephron; u106nephrons the bladderCortexMedullaCapsuleRenal arteryGlomerulusBowman s capsuleProximal tubuleDistal tubuleCollecting ductHenle sLoopAfferent arterioleDr.

1 The Kidneys Dr. Khalid Al-Ani Department of Clinical Pharmacy Faculty of Pharmacy Lecture-4 Renal Functions Excretion of waste -Production of urine

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