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Revised National Tuberculosis Control Programme DOTS-Plus Guidelines Central TB Division, Directorate General of Health Services, Ministry of Health & Family Welfare, Nirman Bhavan, New Delhi 110011 Revised National Tuberculosis Control Programme DOTS-Plus Guidelines January 2010 Central TB Division, Directorate General of Health Services, Ministry of Health & Family Welfare, Nirman Bhavan, New Delhi 110011 Staff members at the Central Tuberculosis Division, Ministry of Health and Family Welfare, New Delhi, the Lala Ram Sarup Institute of Tuberculosis and Allied Diseases, New Delhi, the National Tuberculosis Institute, Bangalore, the Tuberculosis Research Centre, Chennai, and the World Health Organization, New Delhi, contributed to the development of the

1 INTRODUCTION The emergence of resistance to drugs used to treat tuberculosis (TB), and particularly multidrug-resistant TB (MDR-TB), has become a significant public health problem in a number of countries and an obstacle to

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