Solid Dispersions: An Overview To Modify …
International Journal of PharmTech ResearchCODEN (USA): IJPRIF ISSN : 0974-4304 , , pp 1338-1349, Oct-Dec 2009Solid Dispersions: An Overview To ModifyBioavailability Of Poorly Water Soluble DrugsRuchi Tiwari1*, Gaurav Tiwari1, Birendra Srivastava2 and Awani K. Rai11Pranveer Singh Institute of Technology, Dept. of Pharmaceutics, Kalpi Road, Bhauti,Kanpur-208020, Uttar Pradesh, India2Jaipur National University, Jagatpura, Jaipur, Rajasthan, IndiaINTRODUCTIONAn ideal drug delivery system should be able to deliveran adequate amount of drug, preferably for an extendedperiod of time for its optimum therapeutic activity. Mostdrugs are inherently not long lasting in the body andrequire multiple daily dosing to achieve the desired bloodconcentration to produce therapeutic activity.
Gaurav Tiwari et al/Int.J. PharmTech Res.2009,1(4) 1339 gastrointestinal solubility and high permeability. By improving the drug release profile of these drugs, it is possible to enhance their bioavailability and reduce side
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