Statistical practice in high-throughput screening data ...

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NATURE BIOTECHNOLOGY VOLUME 24 NUMBER 2 FEBRUARY 2006 167Statistical practice in high - throughput screening data analysisNathalie Malo1,2, James A Hanley2, Sonia Cerquozzi1, Jerry Pelletier3 & Robert Nadon1,4High- throughput screening is an early critical step in drug discovery. Its aim is to screen a large number of diverse chemical compounds to identify candidate hits rapidly and accurately. Few Statistical tools are currently available, however, to detect quality hits with a high degree of confidence. We examine Statistical aspects of data preprocessing and hit identification for primary screens.

NATURE BIOTECHNOLOGY VOLUME 24 NUMBER 2 FEBRUARY 2006 167 Statistical practice in high-throughput screening data analysis Nathalie Malo 1,2, James A Hanley 2, Sonia Cerquozzi 1, Jerry Pelletier3 & Robert Nadon 1,4 High-throughput screening is an early critical step in drug discovery.

  High, Analysis, Practices, Data, Screening, Statistical, Throughput, Statistical practice in high throughput, Statistical practice in high throughput screening data analysis