UK Biobank Protocol

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UK Biobank : Protocol for a large-scale prospective epidemiological resource Protocol No: UKBB-PROT-09-06 (Main Phase) UK Biobank Coordinating Centre 1 & 2 Spectrum Way Adswood Stockport Cheshire SK3 0SA Tel:0161-475-5360 Fax:0161-475-5361 E-mail: 21 March 2007 (AMENDMENT ONE FINAL)2 Contents Page 1 Scientific rationale and design Overall aims of UK Biobank prospective resource 3 Rationale for large size 6 Background to baseline questionnaire 17 Background to baseline physical measurements 23 Background to baseline samples 31 Planning and piloting 38 Assessment centre planning 49 2 Development of the resource Overall strategy 56 Identification and invitation 57 Baseline assessment 63 Sample processing 73 Potential for enhancements 78 Long-term follow-up 81 Data handling and security 89 Strategy for access 96 Organisation 100 Annexes 1 UK Biobank committees and staff 105 2 References 107 3 1.

3 1. SCIENTIFIC RATIONALE AND DESIGN 1.1 Overall aims of UK Biobank prospective resource 1.1.1 Reliable assessment of different causes of disease

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