Lyophilization of Complex Drug Products: Formulation ...

equipped with clean-in-place (CIP) and steam-in-place (SIP) capabilities for ease of cleaning and sterilization. The Lyophilization Process The main principle behind lyophilization is sublimation, a phase transition (Figure 2) wherein a solvent (almost always water) goes directly from solid to gas without becoming a liquid.

  Place, Steam, In place, Steam in place

STEAM IN PLACE (SIP)

SIP (Sterilize, or Steam In Place) is a timed sterilization of the upstream and downstream biopharmaceutical production train using clean steam. It is part of a 5 step sanitization routine that occurs after every production batch, and follows the inal rinse after CIP (Clean In Place). SIP ensures that every square inch of the production train that

  Place, Steam, In place, Steam in place

Rosemount 2120 Level Switch - Emerson Electric

Product Data Sheet 00813-0100-4030, Rev HE March 2022 Rosemount™ 2120 Level Switch Vibrating Fork Designed for operation in process temperatures of –40 to 302 °F (–40 to 150 °C)