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260/280 and 260/230 Ratios - CGIAR

hpc.ilri.cgiar.org

260/230 Ratio This ratio is used as a secondary measure of nucleic acid purity. The 260/230 values for “pure” nucleic acid are often higher than the respective 260/280 values. Expected 260/230 values are commonly in the range of 2.0-2.2. If the ratio is appreciably lower than

  Ratios, 230 ratios

SPECTROPHOTOMETRY (QUANTIFICATION OF NUCLEIC ACIDS

hpc.ilri.cgiar.org

•Pure DNA sample gives a 260:280 ratio of ˷1.8 and for pure RNA the ratio is ˷ 2. •A260/230 ratio indicates the presence of organic contaminants, such as (but not limited to): phenol, TRIzol, chaotropic salts and other aromatic compounds. Samples with 260/230 ratios below 1.8 are considered to have a

  Ratios, 230 ratios

Interpreting Nanodrop (Spectrophotometric) Results

www.u.arizona.edu

pure sample, the A260/230 should be close to 2.0 Real World Examples: The absorbance spectrum of the RNA sample below indicates a high purity with close to ideal A260/280 and A260/230 ratios. Also note that the concentration is within the reliable range of …

  Ratios, Interpreting, Results, Spectrophotometric, Nanodrop, Interpreting nanodrop, 230 ratios

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