VESICLES & BULLAE: A REVIEW OF DIFFERENTIAL DIAGNOSES …

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Staph Scalded Skin Syndrome (SSSS) Pathogenesis: Infection by S. aureus phage group II (types 55 and 71) at distant site→ produceexfoliatoxins A and B (ETA and ETB) →exfoliatoxins disseminate via bloodstream widespread cleavage of desmoglein 1→diffuse subcorneal acantholysis Clinical features: Children esp those with ↓renal clearance (low mortality <5%) >

  Skin, Staph, Staph scalded skin, Scalded