Rheoswitch -Mediated Regulation of IL-12 Protein Delivered ...

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Ef˛cacy Safety Body Weight (%) Tumor Volume (m m 3) Body Weight (%) Tumor Volume (m m 3) 50 mg/kg 73% Ligand Control 1e10 vp Ad-RTS-IL-12 12% 100 mg/kg 91% 250 mg/kg 94% 500, 750 1000 mg/kg 95-98% 125 120 115 110 105 100 95 90 85 80 2,000 1,900 1,800 1,700 1,600 1,500 1,400 1,300 1,200 1,100 1,000 900 800 700 600 500 400 300 200 100 0 125 120 ...

  Safety, Cycas, Cacy safety