Transcription of 1 早期食道癌の病態 - chugaiigaku.jp
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1 早期食道癌の病態 - chugaiigaku.jp
2 . 1 .. 1 .. 1 .. Barrett .. 498 04348. 1 3. 2 . a .. Barrett . 1 . 95 p53 p21 WAF1/CIP1 . p16 INK4a p14 ARF cyclin D1 Rb EGFR COX 2 DNA .. 2 2 p53 DNA .. p53 . p53 p21 WAF1/CIP1 MDM2 p14 ARF p16 INK4a cyclin D1. Bax p53 AIP1 . cyclin D1 Rb . Barrett Barrett .. 5 15 Barrett Barrett Barrett . 1 .. c myc c myc K ras p53 p21 p14 mdm2 p53 p21 p14 mdm2. Rb cyclin D1 p16 Rb cyclin D1 p16. EGFR EGFR. COX 2 COX 2. E cadherin E cadherin FHIT Fas FasL. ADH2 Cdx 2. iNOS iNOS. 498 04348. 4 . Barrett . Barrett Barrett .. b.
1．早期食道癌の病態 3 498―04348 2 早期食道癌の病態 食道の発癌 正常上皮から食道癌が発生する要因として喫煙や飲酒，食事などの環境因子のほか，扁平上皮癌
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