Transcription of 1 早期食道癌の病態 - chugaiigaku.jp
1 2 . 1 .. 1 .. 1 .. Barrett .. 498 04348. 1 3. 2 . a .. Barrett . 1 . 95 p53 p21 WAF1/CIP1 . p16 INK4a p14 ARF cyclin D1 Rb EGFR COX 2 DNA .. 2 2 p53 DNA .. p53 . p53 p21 WAF1/CIP1 MDM2 p14 ARF p16 INK4a cyclin D1. Bax p53 AIP1 . cyclin D1 Rb . Barrett Barrett .. 5 15 Barrett Barrett Barrett . 1 .. c myc c myc K ras p53 p21 p14 mdm2 p53 p21 p14 mdm2. Rb cyclin D1 p16 Rb cyclin D1 p16. EGFR EGFR. COX 2 COX 2. E cadherin E cadherin FHIT Fas FasL. ADH2 Cdx 2. iNOS iNOS. 498 04348. 4 . Barrett . Barrett Barrett .. b.
2 10 . dysplasia low grade intraepithelial neoplasia . high grade intraepithelial neoplasia carcinoma in situ . 1 low grade intraepithelial neoplasia . 1/2 high grade intraepithelial neoplasia 1 .. 2 3 5 . 0 IIb . 0 IIc . 0 IIa 0 IIc 0 IIa 0 IIc 0 IIc . 0 IIa 0 IIc .. 0 III 0 IIa IIc . 2 3 1 . / . low grade intraepithelial neoplasia high grade intraepithelial neoplasia/carcinoma in situ . 1 intraepithelial neoplasia . 498 04348. 1 5. 0 IIa . 0 IIb 0 IIb .. 0 IIc .. 2 . 0 IIb .. matrix metalloproteinase 7 E cadherin.
3 E cadherin catenin catenin .. epithelial mesenchymal transition EMT . slug snail twist . c . EP LPM . MM 7 10 .. 3 . lymphangiogenesis . vascular endothelial growth factor C VEGF C VEGF D .. 498 04348. 6 .. VEGFR 2 3.. VEGF C . VEGF D.. 3 .. 3 .. EP/LPM SM2 3 . MM/SM1 . NBI AFI FICE .. sentinel node navigation .. 498 04348.
