Transcription of 2008 JMPR Evaluations-- PART I
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2008 JMPR Evaluations-- PART I
prothioconazole 1457 prothioconazole (232) First draft prepared by Prof. Dr. Arpad Ambrus, Hungarian Food Safety Office, Budapest, Hungary EXPLANATION prothioconazole is a systemic fungicide with a triazolinthione structure. At the 39th session of the CCPR (ALINORM 07/30/24), it was listed as a candidate for evaluation of new compounds by the 2008 jmpr . The manufacturer submitted information on physical and chemical properties, metabolism, analytical method, environmental fate, supervised trials processing and national registered uses. IDENTITY Common name: prothioconazole Manufacturer's code Number: JAU 6476 Other code numbers: CAS number: 178928-70-6 CIPAC number: 745 Chemical name: IUPAC:2-[(2RS)-2-(1-chlorocyclopropyl)-3 -(2-chlorophenyl)-2-hydroxypropyl]-2H-1, 2,4-triazole-3(4H)-thione CAS:2-[2-(1-chlorocyclopropyl)-3-(2-chlo rophenyl)-2-hydroxypropyl]-1,2-dihydro-3 H-1,2,4-triazole-3-thione Formulae: C14 H15 Cl2 N3 O S Molecular mass Structural formula: NNNHSClClOHRacemate (50:50) PHYSICAL AND CHEMICAL PROPERTIES The manufacturing process is not enatio-selective.
1460 Prothioconazole METABOLISM AND ENVIRONMENTAL FATE The metabolism of prothioconazole in plants and animals was investigated using [phenyl-UL-14 C]-prothioconazole referred to as phenyl-label, and [3,5-triazole-14 C]-labelled parent compound referred to as triazole-label.
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