Transcription of 2010 ACR/EULAR Classification Criteria for Rheumatoid ...
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2010 ACR/EULAR Classification Criteria for Rheumatoid ...
2010 ACR/EULAR Classification Criteria for Rheumatoid ArthritisPublished in the September 2010 Issues of A&Rand ARDP hases of the ProjectPhase 1 Data analysisPhase 2 Consensus processPhase 3 Integration of 1 and 2 Predictors of MTX initiationFinal CriteriaDeterminants of high probability of RAIncrease feasibilityPhase 1 Data Driven ApproachPhase 1: Patients and Methods Patients early arthritis COHORTS 3115 patientsfrom 9 cohorts Inflammatory arthritis (no other definite diagnosis) of <3 years No previous DMARD/MTX treatment Methods PREDICTORS OF MTX TREATMENT Step 1: Univariate regression analysisof all possible variables Step 2: Principal component analysis: identify themes Step 3: Multivariate regression analysiswith all relevant themesPhase 1: Three Analytic StepsUnivariate Regression AnalysisIdentify significant variables at baselineGold standard: MTX treatment at one yearSTEP 1 Principal Component AnalysisIdentify sets of variables representing the same theme STEP 2 Multivariate regression AnalysisIdentify independent effects of variables and their relative contribution ( weight )STEP 3 STEPS 1 and 2: Predictors of MTX initiationLoadings on Factors 1%6 Factor No (Eigenvalue)1 ( )2 ( )3 ( )4 ( )5 ( )6 ( )Anit%Citrullinated peptide AB (0,1,2).
Submit case scenarios of early undifferentiated inflammatory arthritis Rank the case scenarios on probability of developing persistent erosive RA Specify target population Positive factors +-Negative factors Discussion on reasons for discordance among physicians Phase 1 data Identifying domains and categories
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