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Biologics for Psoriasis and Psoriatic Arthritis

Review of Biologic Agents for Psoriasis and Psoriatic Arthritis Updated versions may be found at or 1 Biologics for Psoriasis and Psoriatic Arthritis (Adalimumab, Etanercept, Golimumab, Infliximab, Ustekinumab) National PBM Criteria for Use Monograph with Literature Review June 2013 VA Pharmacy Benefits Management Services, Medical Advisory Panel, and VISN Pharmacist Executives The purpose of VA PBM Services drug monographs is to provide a comprehensive drug review for making formulary decisions. These documents will be updated when new clinical data warrant additional formulary discussion. Documents will be placed in the Archive section when the information is deemed to be no longer current. EXECUTIVE SUMMARY The purposes of this updated review of antipsoriatic biologic agents are to compare their pharmacologic properties and evaluate studies that address certain key clinical questions that are pertinent to the development of criteria for use of biologic agents for chronic plaque Psoriasis (CPP) and Psoriatic Arthritis (PsA) in the Veterans Health Administration.

early, unconfirmed evidence that, although biologic agents may be more effective than nonbiologic treatments, ... For psoriatic arthritis, the evidence is unclear about whether any biologic is better than the others. Biologics seem to be more efficacious than nonbiologic systemic agents, particularly methotrexate, based on indirect comparisons ...

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