4.1.3. BUFFER SOLUTIONS - DrugFuture

EUROPEAN PHARMACOPOEIA BUFFER solutionsZirconium standard solution (1 g/L Zr). nitrate Requivalent to g ofZrO(NO3)2,2H2 Oinamixtureof2volumesofhydrochloricacid Rand 8 volumes ofwater Rand dilute to mL withthe same mixture of BUFFER SOLUTIONSB uffered acetone g ofsodium acetate Rand 42 g ofsodiumchloride Rinwater R, M hydrochloric acidand 150 mL ofacetone Rand dilute to 500 mL withwater solution pH g ofpotassium chloride Rinwater Rand mL M hydrochloric acid. Dilute to mL withwater BUFFER solution pH g ofdisodium hydrogen phosphate Rand gofpotassium dihydrogen phosphate Rinwater Rand diluteto mL with the same solvent. If necessary adjust thepH withphosphoric acid BUFFER solution pH g ofammonium sulfate Rinwater Rand diluteto mL with the same solvent (Solution A). Carefully andwith constant cooling stir 14 mL of sulfuric acid R into about400 mL ofwater R; allow to cool and dilute to mL withwater R(Solution B).

4.1.3. Buffer solutions EUROPEAN PHARMACOPOEIA 7.0 Succinate buffer solution pH 4.6.4001500. Disssolve 11.8 g ofsuccinic acid R in a mixture of 600 mL of water R and 82 mL of 1 M sodium hydroxide and dilute to

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