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A Basic Guide to Autoimmune Testing: Part I ANA, ENA and ...

A Basic Guide to Autoimmune testing : part I ANA, ENA and dsDNA Antibodies Typical scenario: A 40 year old woman presents with tiredness. She requests Autoimmune tests just to make sure , as a friend was diagnosed with Lupus some years back and has been quite unwell. She has looked it up on the internet. Blood tests reveal a normal full blood count, normal ESR, and lowish ferritin. Her ANA is 1/160, speckled pattern. A Reminder: The Clinical Manifestations of Lupus Systemic Lupus Erythematosus (SLE, or Lupus) is a complex Haematological Anaemia, low platelets, neutropenia Autoimmune disease, which may Photosensitivity, rashes, alopecia, Raynauds, acrocyanosis, present with a variety of clinical Skin mouth ulcers symptoms and signs.

Page 2 of 3 A Basic Guide to Autoimmune Testing: Part I ANA, ENA and dsDNA Antibodies continued 3. The Management of patients with unexpected autoantibody positivity Bagnasco et al,

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