Transcription of Acid-Base Disorders - UCSF CME
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Acid-Base Disorders - UCSF CME
Acid-Base DisordersSharon Anderson, of Nephrology and HypertensionOregon Health & Science UniversityPortland VA Medical CenterOctober 2012 UCSF 2012 General Acid-Base RelationshipsHenderson Hasselbach equation:pH = pK + log HCO3_/pCO2H+= 24 x pCO2/HCO3_ pH unit = 10 nm/L H+Approach to Acid-Base Disorders1. Consider the clinical setting!2. Is the patient acidemic or alkalemic?3. Is the primary process metabolic or respiratory?4. If metabolic acidosis, gap or non-gap?5. Is compensation appropriate?6. Is more than one disorder present?Simple Acid-Base DisordersConditionpHPrimary DisorderCompensationMetabolic acidosis pH HCO3 pCO2 Metabolic alkalosis pH HCO3 pCO2 Respiratory acidosis pH pCO2 HCO3 Respiratory alkalosis pH pCO2 HCO3 Expected Compensatory ResponsesMetabolic Acidosis Etiology: Inability of the kidney to excrete the dietary H+load, or increase in the generation of H+(due to addition of H+ or loss of HC)
Approach to Acid-Base Disorders 1. Consider the clinical setting! 2. Is the patient acidemic or alkalemic? 3. Is the primary process metabolic or respiratory?
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