Transcription of Adipose Tissue and Adipocyte Differentiation: …
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Adipose Tissue and Adipocyte Differentiation: …
S. Niemel *, S. Miettinen, Sarkanen and N. Ashammakhi Summary H uman Adipose Tissue represents an abundant, practical and appealing source of donor Tissue for autologous cell replacement. Recent results have shown that stem cells within the stromal-vascular fraction of Adipose Tissue display a multilineage developmental potential. Adipose Tissue -derived stem cells can be differentiated towards adipogenic, osteogenic, chondrogenic, myogenic and neurogenic lineages. To take full advantage of this new technology, it will be necessary to understand Adipose Tissue -specific signalling cascades and genes regulating Adipose Tissue -derived stem cell differentiation to various mesenchymal lineages. Adipocyte differentiation is an ordered multistep process requiring the sequential activation of several groups of transcription factors, including CCAAT/enhancer-binding protein (C/EBP) gene family and peroxisome proliferator-activated receptor- (PPAR- ).
S. Niemelä*, S. Miettinen, J.R. Sarkanen and N. Ashammakhi Summary H uman adipose tissue represents an abundant, practical and appealing source of donor tissue for autologous cell replacement. Recent results have …
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