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Antibody Responses to SARS-CoV-2

October 20, 2020 Edition 2020-10-20 Page 1 of 14 ** Available on-line at ** Understanding the immune response to SARS-CoV-2 infection is important to comprehend factors that may play a role in mitigating the epidemic such as whether persons develop lasting immunity after recovery from infection and the optimal vaccine-induced immunity to provide adequate protection. Additionally, understanding the timing of Antibody response and neutralizing activity can help direct optimal timing for convalescent plasma donation. Here we present three papers evaluating the magnitude, duration, and predictors of IgG, IgM, IgA, and neutralizing Antibody Responses to SARS-CoV-2 .

nAb titers. Methods: Samples from 250 adults recovering from RT-PCR-confirmed SARS-CoV-2 infection and participating in a convalescent plasma donor screening program were tested for IgG to SARS-CoV-2 spike protein S1 domain, spike protein nucleoprotein, and nAb. Analyses modeled predictors of high nAb titers (≥: ì, the US Food and Drug

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