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Antidiabetic Medication Comparison Chart

Antidiabetic Medication Comparison Chart Generic Name Brand name Expected % decrease in A1c* Hypoglycemia in monotherapy Weight Renal/GU GI SX CHF CVD Bone Health Other considerations Effect on blood glucose Site of action Cost $ Alpha-Glucosidase Inhibitors Acarbose^ (Precose) Neutral Neutral Neutral Moderate Neutral Neutral Neutral Take with first bite of food Post prandial Intestines liver 100 Miglitol(Glyset) Neutral Neutral Neutral Moderate Neutral Neutral Neutral Take with first bite of food Post prandial Intestines liver 200 Biguanide Metformin^ (Foramet, Glucophage, Glucophage XR, Glumetza, Riomet) 1-2 Neutral Slight loss Cont. CKD stage 3B, 4, 5 Crcl 45-60: monitor Crcl 30-45: decrease dose and monitor Moderate Neutral (if stable) Benefit Neutral Lactic acidosis risk increases with increased age, CHF, and hepatic insufficiency Fasting & Basal Liver Intestines muscles 4 Dipeptidyl Peptidase IV (DPP-4) Inhibitors Alogliptin (Nesina) Neutral Neutral Dose adj.

0.5-1.4 Neutral Gain Can worsen fluid retention Neutral Moderate Monitor Neutral May reduce stroke risk Moderate fracture risk Edema Bladder CA Up to 3 months for full effect Fasting & Basal Muscles Body fat 200 Sulfonylureas (SU) Glimepiride^ (Amaryl) 1-2 Moderate to severe Gain >risk of hypo and fluid retention Neutral Slight risk increase

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