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Basic Concepts in Pharmacokinetics - Warwick

Leon Aarons Manchester Pharmacy School University of Manchester Basic Concepts in Pharmacokinetics Objectives Pharmacokinetics absorption distribution elimination Why do we study PK? We administer drugs (dose) because we seek a certain effect (response), but a complex chain of events links the administered dose to the observed response Pharmacokinetics Pharmacodynamics Drug concentration Image from PK is based on the analysis of drug concentrations. After one or more doses ( ), the drug concentration in the desired matrix is measured (- -). (L)ADME The processes that characterize PK are summarized in the (L)ADME scheme.

Relationship of PK parameters ( ) CL ln 2 V t 2 1 ⋅ = The elimination half-life is defined as the time for the drug concentration to reach half of its value.

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