Transcription of Basic pharmacokinetics - Pharmaceutical Press
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Basic pharmacokinetics - Pharmaceutical Press
Aims and learning outcomesPharmacokinetics is a fundamental scientific discipline that underpinsapplied therapeutics. Patients need to be prescribed appropriate medicinesfor a clinical condition. The medicine is chosen on the basis of an evidence-based approach to clinical practice and assured to be compatible withany other medicines or alternative therapies the patient may be design of a dosage regimen is dependent on a Basic under-standing of the drug use process (DUP). When faced with a patient whoshows specific clinical signs and symptoms, pharmacists must alwaysask a fundamental question: Is this patient suffering from a drug-relatedproblem? Once this issue is evaluated and a clinical diagnosis is avail-able, the pharmacist can apply the DUP to ensure that the patient is prescribed an appropriate medication regimen, that the patient under-stands the therapy prescribed, and that an agreed concordance plan using the DUP consider: Need for a drug Choice of a drug Goals of therapy Design of regimen Route Dose and frequency Duration Monitoring and review CounsellingOnce a particular medicine is chosen, the pr
Pharmacokinetic models Pharmacokinetic models are hypothetical structures that are used to describe the fate of a drug in a biological system following its administration. One-compartment model Following drug administration, the body is depicted as a kinetically homo-geneous unit (see Figure 1.1). This assumes that the drug achieves instant-
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