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Biochemistry Metabolic pathways - Limes-Institut-Bonn

Biochemistry Metabolic pathways Gerhild van Echten-Deckert Tel. 73 2703. E-mail: Objectives of the course: Energy metabolism high-energy donors coupled reactions co-factors: NAD+/NADH; FAD/FADH2; TPP; PLP; CoA; Biotin glycolysis/glyconeogenesis citric acid cycle: regulation (tissue-dependent). GABA-shunt;. glyoxylate cycle respiratory chain and oxidative phosphorylation glycogen metabolism (activated glucose). pentose phosphate pathway (tissue specificity). photosynthesis: RUBISCO. C4-plants Nitrogen metabolism N2 assimilation via reduction to NH3 (nitrogenase complex). NH3 metabolism: glutamate-dehydrogenase glutamate synthase glutamine synthetase glutamine amidotransferase urea cycle C1 metabolism (PLP, THF, SAM, homocystein). nucleotide metabolism: biosynthesis of purines and pyrimidines from RNA to DNA (NDP reductase).

Metabolic Pathways are Compartmentalized within Cells • Eukaryotic cells are compartmentalized by an endomembrane system – advantageous for metabolism • Each organelle (compartment) – dedicated to specialized metabolic functions and contains appropriate enzymes – confined together. • Advantages:

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