Transcription of Steroidogenic Pathways - GDX
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Steroidogenic Pathways - GDX
3 HSD3 HSD17,20 Lyase17,20 LyaseCYP2117-hydroxylase17-hydroxylaseCY P21 CYP11b15 5 5 11 HSD3 HSD3 HSDCOMTCOMT17 HSD3A41A15 3 HSD17 HSD1B117 HSD5 5 17 HSDA romatase (CYP19)Aromatase (CYP19)11-DeoxycortisolCorticosteronePre gnanediolPregnanetriola-THFTHFTHE2-MeO(E 1+E2)2-OH(E1+E2)16a-OHE14-OH(E1+E2)4-MeO (E1+E2)EtiocholanoloneAndrosteroneAndros tanediolCholesterolPregnenoloneProgester one17-OH-Progesterone17-OH-PregnenoloneA ndrostenedioneDHEAA ndrostenediolEstrone (E1)Estriol (E3)Estradiol (E2)DHTT estosteroneCortisol(active)(inactive)Cor tisoneCongenital adrenal hyperplasia (CAH), smoking, E2, progesterone, azole antifungals, spironolactoneCrucifers, berries, I3C, DIM, soy, flaxseed, caffeine, rosemary, exercise, thyroxineExcess sugar or n6 fats, cimetidine, OCPsHypothyroidism, pesticide exposure, smoking, caffeine, various medicationsGrapefruit, peppermint oil, rosemary, wild yam, anti-fungals & other medicationsCeliac disease, 5 -reductase inhibitors ( , finasteride, saw palmetto, pygeum, stinging nettle), flaxseed.
metabolic syndrome, hypothyroid, inflammation, essential HT, cortisol resistance, cholestasis, hypoxia, licorice, (via IGF-1), vitamin D, coff grapefruit, forskolin ... Steroidogenic Pathways Measurable in Urine Measurable in Blood Measurable in Saliva Measurable in Urine Measurable in Blood Measurable in Saliva Measurable in Urine
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