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COMMENTARy Calcium and phosphates COMMENTARy Calcium and phosphate compatibility : The influence of other drugs and ,10-18. Revisited again The application of knowledge about Calcium and phosphate com- David W. Newton and David F. Driscoll patibility in therapy has been fa- Am J Health-Syst Pharm. 2008; 65:73-80 cilitated by four hallmark articles,3-6. several editions of the Handbook on T. he subject of the compatibility The clinically relevant dissocia- Injectable Drugs17 since 1983, and between Calcium and phosphates tion equilibria for which the pKa2 of Trissel's Calcium and phosphate Com- was revisited in an April 1994 phosphoric acid is ( , the pH patibility in Parenteral FDA safety alert,1,2 6 16 years after at which the concentrations or, ther- Despite the availability of these the four seminal research articles modynamically, the ionic activities of literature sources, Calcium and phos- appeared in 1978, 3 1980, 4 1982, 5 HPO42 and H2PO4 are equal) (Table phate compatibility continues to be a and In the 1980s there were 1): clinical enigma.
COMMENTARy Calcium and phosphates Am J Health-Syst Pharm—Vol 65 Jan 1, 2008 73 COMMENTARy Calcium and phosphate compatibility: Revisited again Dav i D W. Ne W t o N a ND Dav i D F. Driscoll Am J Health-Syst Pharm. 2008; 65:73-80 Dav i D W. N e W to N, B.S.Pharm., Ph.D., FaPha, is Professor and Chairman, Depart- ment of Biopharmaceutical Sciences, Ber-
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