Transcription of Carcinogenic Risk Factors - Med
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Carcinogenic Risk Factors - Med
JMAJ, June 2001 Vol. 44, No. 6245 Carcinogenic Risk FactorsJMAJ 44(6): 245 249, 2001 Hiroshi SAEKI* and Keizo SUGIMACHI**Assistant Professor and **Professor, Department of Surgery and Science,Graduate School of Medical Sciences, Kyushu UniversityAbstract: Carcinogenic risk Factors can be roughly divided into environmentalfactors and genetic Factors . Environmental Carcinogenic Factors include the follow-ing: ionized radiation, etc. as physical Factors ; benzo [ ] pyrene contained in tobaccosmoke, ethyl alcohol, etc. as chemical Factors ; and various viruses, etc. as biologicalfactors. Meanwhile, abnormalities in DNA repair genes and cell cycle genes havebeen identified as genetic Factors . Now that the mechanisms of carcinogenesis havebeen understood from a genetic standpoint, relationships between risk Factors andcarcinogenesis have also become comprehensible from the viewpoint of gene abnor-malities.
JMAJ, June 2001—Vol. 44, No. 6249 to be an autosomal dominant hereditary dis-ease associated with inherited mutation in the p53 gene.10) Conclusion As carcinogenic risk factors, environmental
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