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Cardiogenic Shock

Cardiogenic ShockMichael Liston Cardiogenic Shock (CS) is a clinical condition of inadequate tissue(end organ) perfusion due to cardiac dysfunction Hypotension (SBP < 80-90 mmHg) or MAP 30 mmHg below baseline Reduced cardiac index(< L/min per m2) < L/min per m2 with support Adequate or elevated filling pressuresDifferentiating types of Shock Etiology PCWP CO SVR SVO2 Hypovolemic v v ^ vCardiogenic ^ v ^ vSeptic v or = ^ v ^Prevalence Occurs in 5-8% of STEMI and of NonSTEMI 40,000-50,000 cases annually in the USMortality Current registries suggest a mortality rate of about 50% Historically rates quoted as high as 80-90% With early revascularization, newer modalities and aggressive treatment rates improvingMortality Risks Older age Female sex Anterior wall STEMI Hypertension Type II Diabetes MultivesselCoronary Artery Disease Prior STEMI or Angina STEMI with new LBBB History of Heart FailureEtiology Acute myocardial infarction with left ventricular failure (or rv failure)

Beta Blockers, Ace Inhibitors, MSo4 decrease bp, slow heart rate and decrease in cardiac contractility may cause CS in certain High Risk patients • Diuretics-in some patients pulmonary edema due to decreased LV compliance and net redistribution of intravascular volume to the lungs-further decline in circulating intravascular volume

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