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Cell Culture Optimization Using anAgilent Bio-Monolith Protein AColumn and LC/MS AuthorsEmmie Dumont, Isabel Vandenheede, Pat Sandra, Koen SandraResearch Institute for Chromatography(RIC) President Kennedypark 26B-8500 Kortrijk BelgiumJames Martosella, Phu Duong, Maureen Joseph Agilent Technologies, IncApplication NoteBiopharmaceuticals and BiosimilarsAbstractThis application note describes how the Agilent Bio-Monolith Protein A column wasapplied to the Optimization of Chinese hamster ovary cell- Culture conditions toproduce a recombinant monoclonal antibody with desired structural characteristics,focusing on glycosylation. The workflow demonstrates the versatility and wideapplicability of the column in biopharmaceutical and biosimilar development. 2 IntroductionMonoclonal antibodies (mAbs) represent the fastest growingclass of therapeutics. Currently, more than 30 monoclonalantibodies are marketed and several have acquired majorimportance in the recent past [1]. The knowledge that thetop-selling mAbs are, or will become, open to the market inthe coming years has resulted in an explosion of biosimilaractivities.
Cell Culture Optimization Using an Agilent Bio-Monolith Protein A Column and LC/MS Authors Emmie Dumont, Isabel Vandenheede, Pat Sandra, Koen Sandra
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