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Chapter 13: Measles; Epidemiology and Prevention of ...

Measles Measles is an acute viral infectious disease. References to measles can be found from as early as the 7th century. The Measles disease was described by the Persian physician Rhazes in the Highly contagious viral illness 10th century as more to be dreaded than smallpox. First described in 7th century In 1846, Peter Panum described the incubation period Near universal infection of measles and lifelong immunity after recovery from the of childhood in disease. Enders and Peebles isolated the virus in human prevaccination era and monkey kidney tissue culture in 1954.

Measles virus is rapidly inactivated by heat, sunlight, acidic pH, ether, and trypsin. Pathogenesis. Measles is a systemic infection. The primary site of infection . is alveolar macrophages or dendritic cells. Two to three days . after replication in the lung, measles virus spreads to regional . lymphoid tissues followed by a systemic infection ...

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