Transcription of Chapter 4 The Dose-Response Relationship
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Chapter 4 The Dose-Response Relationship
Chapter 4 The Dose-Response Relationship Introduction The need to establish some criteria to base the relative safety of chemicals is essential. Several methods are used to obtain data in order to establish safe levels and provide information about the relative toxicity of chemicals. Acute Toxicological Studies (1) Information concerning the toxicity of a substance is obtained primarily from either acute or chronic toxicity studies. Acute toxicity studies are the most commonly performed studies for obtaining information on the effects of chemical exposure. They are short-term, relatively inexpensive tests with death of the test animal being the useful observed effect. Information obtained from acute toxicity tests can be used to determine the relative toxicity of different chemicals comparing the respective LD50 values, which are the doses that prove to be lethal for 50 percent of the test animals; identify the target organs (heart, liver, kidneys, etc.)
Acute Toxicological Studies (1) • Information concerning the toxicity of a substance is obtained primarily from either acute or chronic toxicity studies. • Acute toxicity studies are the most commonly performed studies for obtaining information on the effects of chemical exposure.
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