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Copyright 2008, The Johns Hopkins University and Simon Day. All rights reserved. Use of these materials permitted only in accordance with license rights granted. Materials provided AS IS ; no representations or warranties provided. User assumes all responsibility for use, and all liability related thereto, and must independently review all materials for accuracy and efficacy. May contain materials owned by others. User is responsible for obtaining permissions for use from third parties as work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this , Surrogates, Composite EndpointsSimon Day, PhDJohns Hopkins UniversitySection AOutcomes and Endpoints4 What Are They? Synonyms Response variables Outcome measures Functional definition What the trial is measuring How it is measured5 Definitions Outcomes measured during the course of the trial and they defineand answer the question (Friedman, Furberg, and DeMets) A result, condition, or event associated with individual study patients that is used to assess the efficacy of the study treatment (Meinert)6 Definitions.

5 Definitions Outcomes measured during the course of the trial and they define and answer the question (Friedman, Furberg, and DeMets) A result, condition, or event associated with individual study

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