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Chapter 5: Major Metabolic Pathways

1 Michigan Technological UniversityDavid R. Shonnard1 Chapter 5: Major Metabolic PathwaysDavid ShonnardDepartment of Chemical EngineeringMichigan Technological UniversityMichigan Technological UniversityDavid R. Shonnard2 Presentation Outline:lIntroduction to MetabolismlGlucose MetabolismGlycolysis, Kreb s Cycle, RespirationlBiosysthesislFermentation2 Michigan Technological UniversityDavid R. Shonnard3 Metabolismis the collection of enzyme-catalyzed reactions that convert substrates that are external to the cell into various internal Technological UniversityDavid R. Shonnard4 Genetic Engineeringallows for the alteration of metabolism by insertion or deletion of selected genes in a predetermined manner ( Metabolic Engineering).

Respiration (Fig. 5.6) “Bioprocess Engineering: Basic Concepts Shuler and Kargi, Prentice Hall, 2002 Oxidative Phosphorylation Goals of Respiration 1. Regenerate NAD+ 2. Generate ATP David R. Shonnard Michigan Technological University 24 Biosynthesis The EMP pathway and TCA cycle are used for catabolism (Glucose → CO 2+ NADH + ATP)

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