CHAPTER CARDIOVASCULAR DRUGS

CHAPTER CARDIOVASCULAR DRUGS The American Heart Association estimates that greater than 50% of deaths are related to some form of CARDIOVASCULAR disease, and many of these may be effectively prevented by appropriate external intervention. CARDIOVASCULAR DRUGS can be broadly categorized as 1) anti-anginals, 2) anti-arrhythmics, 3) anti-hypertensives, 4) anti-coagulants, 5) anti-hyperlipidemic agents, 6) hypo-glycemic agents, and 7) anti-thyroid DRUGS and thyroid hormones. This CHAPTER includes a discussion of the first four categories. ANTI-ANGINAL DRUGS Introduction Anti-anginals are pharmaceutical agents used to treat angina pectoris, a disease of the coronary arteries. The coronary arteries supply oxygen-laden blood from the left ventricle to all heart muscles including those of the ventricles themselves. Coronary arteries maintain cardiac function and are expected to adapt to sudden demands on the heart due to enhanced activity.

muscle cells. Calcium channel antagonists that bind these L-type channels cause antagonism and are effective as anti-anginal agents. These agents do not physically block the channel, but bind at specific sites in the open form of the channel. Chemistry Three classes of calcium channel blockers are currently approved for use in the

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  Drug, Chapter, Cardiovascular, Channel, Blockers, Calcium, Calcium channel blocker, Calcium channel, Chapter cardiovascular drugs

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