Transcription of Charge-mediated influence of the antibody variable domain ...
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Charge-mediated influence of the antibody variable domain ...
Charge-mediated influence of the antibody variabledomain on FcRn-dependent pharmacokineticsAngela Schocha, Hubert Kettenbergerb, Olaf Mundiglc, Gerhard Winterd, Julia Engertd, Julia Heinricha,and Thomas Emricha,1aLarge Molecule Bioanalytical Research and Development, Pharmaceutical Sciences,bLarge Molecule Research Biochemical and Analytical Research, LargeMolecule Research, andcLarge Molecule Research Discovery, Large Molecule Research, Roche Pharmaceutical Research and Early Development, RocheInnovation Center Penzberg, 82377 Penzberg, Germany; anddInstitute of Pharmaceutical Technology and Biopharmaceutics, Ludwig MaximiliansUniversity, 81377 Munich, GermanyEdited by Jeffrey V. Ravetch, The Rockefeller University, New York, NY, and approved April 3, 2015 (received for review May 20, 2014)Here, we investigated the influence of the variable fragment (Fv)of IgG antibodies on the binding to the neonatal Fc receptor (FcRn)as well as on FcRn-dependent pharmacokinetics (PK).
pharmacokinetics (PK) (10). Briakinumab is an IgG1λ antibody with variable heavy and light chain domains of the V H3 and Vλ1 germ-line families. Ustekinumab is an IgG1κ antibody with var- iable heavy and light chain domains of the V
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