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【ガイドライン】 - chemotherapy.or.jp
446 JULY 2012.. 2010 .. 2010 12 .. PK-PD .. 2012 .. 4 . 2012 4 60 .. VOL. 60 NO. 4 447.. I 448. II 448. 1 448. 2 450. 3 450. 4 452. III PK-PD 453. 1 453. 2 454. 3 455. 4 456. 5 456. 6 PK-PD 456. IV 457. 1 457. 2 458. 3 458. 1 458. 2 458. 4 458. V 459. 1 459. 1 459. 2 459. 3 459. 2 460. 1 460. 2 461. 3 461. 3 462. 1 462. 2 462. 3 462. 4 462. 1 462. 448 JULY 2012.. I .. NDM-1 1 .. I .. II . Executive Summary 1 . 2 .. 3 LPS . 4 . 5 in vitro in vivo . 1 . E Bacillus colistinus . 1950 1 .. 2 4 1 . 5 7 B 1 .. VOL. 60 NO. 4 449. Taina Litwak 2007. Reproduced with permission. 1. 8 . Polymyxin .. lipopolysaccharide LPS . LPS .. 450 JULY 2012. 1. 2. 9 10 .. MIC g/mL .. CLSI 2 4 8. 2 4. EUCAST 4 8. 2 4. 2 4.. 2 .. 1 .. 2 CLSI Clinical and Laboratory Standards Institute MIC Minimum Inhibitory Concentration 2 g! mL . 4 g! mL 8 g! mL 2 g! mL 4 g! mL 9 EUCAST European Committee on Antimicrobial Susceptibility Testing.
コリスチンの適正使用に関する指針 i．はじめに 注射用コリスチンメタンスルホン酸（以下，コリスチン注射剤）は，かつてわが国でも臨床使用されていた抗菌薬
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