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CLINICALLY IMPORTANT DRUG INTERACTIONS

CLINICALLY IMPORTANT drug RANIPROFESSOR & HODDEPARTMENT OF PHARMACOLOGYDRUG INTERACTION A REVIEWDrug interaction refers to modification of response to one drug by another when they are administered simultaneously or in quick succession. The modification is mostly quantitative, the response is either increased or decreased in intensity, but sometimes it is qualitative, an abnormal or a different type of response is produced. Many medical conditions are treated with a combination of drugs and drug inhibitors + diuretics to treat hypertension + trimethoprim to treat bacterial infection + amiloride to prevent Probenecid + penicillin used in gonococcal Allopurinol + 6-Mercaptopurine & Azathioprine inhibition of metabolism; Reduce dose of 6-MP/azathioprine to 1/3 and used in cancer IMPORTANT drug INTERACTIONSPRECIPITANT DRUGOBJECT DRUGLIKELY INTERACTION AND COMMENTS1. AmpicillinAmoxicillinTe t ra c y c l i n e sOral contraceptivesInterruption of enterohepatic circulation of the estrogen failure of contraception;Advised alternative contraception2.

The modification is mostly quantitative, i.e the response is either increased or decreased in intensity, but sometimes it is qualitative, i.e. an abnormal or a different

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