Transcription of Complement determinations in human disease - …
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Complement determinations in human disease - …
CME review articleThis feature is supported by an unrestricted educational grant from AstraZeneca LPComplement determinations in human diseaseM. Michael Glovsky, MD*; Peter A. Ward, MD ; and Kent J. Johnson, MD Objective:To define techniques used for Complement measurements and examine the clinical relevance of alterations ofcomplement determinations in Sources:Data have been assembled from the authors research, original articles, and reviews, as well as chapters andcomplete books on Selection:Studies were chosen for inclusion by the opinions of the authors, relevant Complement reviews, publications,and : Complement has been shown to possess approximately 31 proteins, some of which are enzymes (C1r, C1s, C2, factorB, factor D), some cofactors, some inhibitors or inactivators, and others composed of membrane-integrated proteins. All of thecomplement proteins have been purified, and many of the respective genes have been identified.
Another assay system uses rate nephelometry. This tech-nique takes advantage of the fact that the interaction of antigen and antibody in solution leads to the formation of a
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