Transcription of Coupling Reagents - Bachem
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Coupling Reagents - Bachem
NHCOOHRHC PG1NH2 COORHC PG2 NHCORHC PG1 NHCOORHC PG2 COUPLINGREAGENTSC oupling Reagents2 Coupling Reagents AND ADDITIVES OFFERED BY BACHEMThe Coupling reaction the formation of an amide bond between amino acids and/or peptides is the crucial step in peptide synthesis. The reaction consists of two consecu-tive steps:1. Activation of the carboxy moiety2. Acylation of the amino groupDuring the first step the protected amino acid (or peptide) reacts with a so-called Coupling reagent yielding a reactive intermediate. The chemistry behind and the most important Coupling Reagents will be presented in this brochure.
Coupling Reagents 2. COUPLING REAGENTS AND . ... amino acid. PG, PG’: protecting groups. Act: activating group. Coupling Reagents 4 tendency to racemize considerably. Ure-thane derivatives, which include standard α-amino protecting groups as Fmoc, Boc, and Z, of amino acids usually retain their optical purity upon …
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PROTECTING GROUPS, Acid, Amino Groups, Amino, Amino acid, ORTHOGONALITY OF PROTECTING GROUPS, Protecting, Groups, Solid Phase Peptide Synthesis, Strategies and Resins, Review of Organosilanes in Organic Chemistry, Methods in Peptide Synthesis. Part, Amino Acid-Protecting Groups, Protecting Groups Handout A