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Solid Phase Peptide Synthesis, Strategies and Resins

Solid Phase Peptide synthesis , Solid Phase Peptide synthesis , StrategiesStrategiesand and ResinsResins((FmocFmocstrategystrategy)) Bettina QuadeBettina QuadeOutlineOutline IntroductionIntroduction FmocFmoc--basebaselabile Nlabile N protectingprotectinggroupgroup ProtectionProtectionof of thethesidesidechainschains ResinsResins(Wang and (Wang and RinkRinkAmideAmidelinker)linker) CycleCycle::1. 1. attachmentattachmentof of thethefirstfirstNN protectedprotectedaminoaminoacidacid2. 2. deprotectingdeprotectingNN 3. 3. activationactivationand and couplingcouplingof of thetheaminoaminoacidacid4.

Side Chain Protecting Groups Ser, Thr, Tyr: Ether tert-Butylether Asp and Glu: tert-Butylester Lys: boc-protecting group protects the reactive functional group of the amino acid Öprevents formation of branched chains permanent, orthogonal, compatible with Nα-protection Öremain attached troughout the synthesis easy to remove (with acid) after …

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  Phases, Strategies, Group, Acid, Rinses, Synthesis, Protecting, Solid, Peptides, Amino, Amino acids, Protecting groups, Solid phase peptide synthesis, Strategies and resins

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