Transcription of DESeq2: Differential gene expression analysis based on the ...
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Package DESeq2 May 16, 2023 TypePackageTitleDifferential gene expression analysis based on the negativebinomial variance-mean dependence in count data fromhigh-throughput sequencing assays and test for differentialexpression based on a model using the negative (>= 3)VignetteBuilderknitr, rmarkdownImportsBiocGenerics (>= ), Biobase, BiocParallel, matrixStats,methods, stats4, locfit, ggplot2, Rcpp (>= )DependsS4 Vectors (>= ), IRanges, GenomicRanges,SummarizedExperiment (>= )Suggeststestthat, knitr, rmarkdown, vsn, pheatmap, RColorBrewer,apeglm, ashr, tximport, tximeta, tximportData, readr, pbapply,airway, pasilla (>= ), glmGamPoi, BiocManagerLinkingToRcpp, , RNASeq, ChIPSeq, GeneExpression, Transcription,Normalization, DifferentialExpression, Bayesian, Regression,PrincipalComponent, Clustering, documented:AuthorMichael Love [aut, cre],Constantin Ahlmann-Eltze [ctb],Kwame Forbes [ctb],Simon Anders [aut, ctb],Wolfgang Huber [aut, ctb],RADIANT EU FP7 [fnd],NIH NHGRI [fnd],CZI [fnd]Rtopics documented:DESeq2
ij for gene i, sample j are modeled using a Negative Binomial distribution with fitted mean ij and a gene-specific dispersion parameter i. The fitted mean is composed of a sample-specific size factor s j and a parameter q ij proportional to the expected true concentration of fragments for sample j. The coefficients
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