Transcription of DETERGENTS AND THEIR PROPERTIES BEN …
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DETERGENTS AND THEIR PROPERTIES BEN …
DETERGENTS AND THEIR PROPERTIESBEN HANKAMERINSTITUTE FOR MOLECULARBIOSCIENCEUNIVERSITY OF TISSUE TO PROTEINSEIBERT ET AL 1987 J CELL BIOL 105:2257 DETERGENT DEFINITIONDETERGENTS ARE AMPHIPATHIC MOLECULES THAT CONTAIN BOTH APOLAR (HEADGROUP) AND HYDROPHOBIC REGIONS (TAIL). PURIFICATION STABILIZATION CRYSTALLIZATIONSEIBERT ET AL 1987 J CELL BIOL105:2257 PLAY AN IMPORTANT ROLE HEADGROUPS FORM HYDROGEN BONDS WITH TAILS DO NOT FORM H-BONDS AGGREGATE INTO REPLACE LIPIDS DURING SOLUBILIZATION ANDSTABILIZE TRANS-MEMBRANE DOMAINS IN PROTEIN SOLUBILIZATIONPROTEIN: DETERGENT MICELLEBICELLE:PROTEIN COMPLEXPROTEIN:DETERGENTCOMPLEX(NATIVE LIPID)PROTEIN:DETERGENTCOMPLEX(ADDED LIPID)MP EMBEDDED IN A PLANAR LIPIDDETERGENT BILAYERSMALL VESICLESDENATURED PROTEINMAIN CLASSES OF DETERGENTSIONIC DETERGENTS1.
detergents and their properties ben hankamer institute for molecular bioscience university of queensland brisbane b.hankamer@imb.uq.edu.au
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